Question by Wait! U Mad Bro??!!: OK MARIJUANA AND LSD DEBATE?
Allright, so my friend is a smoker right, he doesn’t smoke ALL the time, but he still smokes. so we were having a debate on LSD and Marijuana effect on the brain when they are ABUSED. I said, if you abuse both substances, they could lead to brain damage, but he insists that only LSD does this. He literally says Marijuana will not have an effect on the brain if it is abused. I told him it will and sited a medical book as my source. He then tells me that the book is biased and that he’s done many research on the drug and is sure it doesn’t effect the brain in any way. DOES THAT MAKE SENCE?!!!
well

Best answer:

Answer by bravozulu
Effect should be modified to negative effect. The word “abused” is subjective and even leading. Damage is also somewhat subjective and the word “could” doesn’t have much meaning either. It could be one chance in a billion or 50/50.

THC most definitely has an effect on the brain and it potentially has profound effects on the mind. The changes are due to activating cannabinoid receptors. Those change other neurotransmitters and it changes how the brain functions. There isn’t much long term change and probably no permanent damage. He probably meant that no permanent or even temporary harm was done. That is probably true unless the dose is far beyond normal usage.

LSD is extremely non toxic. The changes are very temporary. This statement from wikipedia is consistent with statements from all the medical doctors I have heard.
“LSD is non-addictive, is not known to cause brain damage, and has extremely low toxicity relative to dose, although in rare cases adverse psychiatric reactions such as anxiety or delusions are possible.”

The later anxiety and delusions are sometimes described as flashbacks and it is generally believed that they are memories of your altered conscious thoughts. You remember feeling paranoid or whatever you experienced so there is potential for permanent psychological damage. The same is logically true for THC though most people don’t normally react badly to it. There are certainly exceptions though.

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